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Can stress really affect your DNA? How stress resilience can slow down genetic aging.

By Ramzy Haddad RPh
25+ years of pharmacy experience. He writes about meaningful applications of Raw DNA analysis , health and wellness.
Reviewed: July 31, 2023
Sources

citochrome wellness uses only high quality, peer reviewed studies and references. The information provided in this article is based on the following literature and variant annotations:

  1. Recalibrating the epigenetic clock after exposure to trauma: The role of risk and protective psychosocial factors. https://www.sciencedirect.com/science/article/abs/pii/ S0022395621006750?via%3Dihub
  2. Menke, A. & Binder, E. B. Epigenetic alterations in depression and antidepressant treatment. Dialogues Clin. Neurosci. 16, 395–404 (2014).
  3. Does the perception that stress affects health matter? The association with health and mortalityhttps://pubmed.ncbi.nlm.nih.gov/22201278/
  4. https://www.health.harvard.edu/mind-and-mood/what-causes-depression

The recent discoveries made by researchers studying the genome are surely of the greatest importance for all of us. The insights give us hope because they show us how we can fix things.

One radical discovery is the DNA. The word radical is derived from a Latin word ‘radix” which is the word for root. And radical means that which deals with the root. What's the root? the root is stress.

But before we go on with the practical, I want to tell you a little bit about the mechanics. Stress is a physical, emotional, or psychological response to events that make you feel overwhelmed or threatened. When we experience stress, our body releases hormones like cortisol and adrenaline to help us cope. These hormones can cause a number of physical and emotional symptoms, including headaches, chest pain, anxiety, and depression

There are different kinds of stress: good stress and bad stress.

Good stress, also known as eustress, can motivate us to meet a deadline at work or perform well in an important meeting. On the other hand, bad stress, or distress, is the kind of stress that overwhelms us and can be too much to manage. This bad stress can lead to mental and even physical health problems. Positive stress is fine. It’s the negative, long-term stress you want to avoid. Negative stress, especially chronic stress, has been shown to increase depression, anxiety, and even reduce your life expectancy. that those exposed to high amounts of stress and perceive stress to affect their health have an increased risk of premature death. Negative stress can also alter your DNA by changing how your DNA expresses certain genes. 

How stress resilience can change your DNA

Epigenetic aging refers to changes to your DNA as you age. These changes can be influenced by lifestyle choices, environmental factors, and (as we now know) stress. If exposed to chronic stress, such as bullying in the workplace or an abusive relationship, neural pathways can develop that may do more harm than good. The amygdala, where the stress response originates in the brain, increases in size over these long stretches of chronic stress. Ultimately, the amygdala becomes more sensitive to stress, resulting in a vicious circle.

How to combat bad stress and help fight genetic aging

Thankfully, research shows that stress is not all doom and gloom. While we can't change our genes, we can influence how they are expressed. This is where stress resilience comes in. When you embrace stressful situations and experiences and develop healthy coping strategies, you build stress resilience, which has been shown to alter your body's cells at a genetic level and could slow down the aging process. By participating in activities that regulate the nervous system, such as meditation, exercise, and other relaxation techniques, we can not only lower the amount of stress we experience at the moment, but also reduce our sensitivity to stress over time. The more we build stress resilience, the more likely we will combat those changes to our DNA.

By strengthening the neural connections between the thinking and emotional parts of our brains, we can increase our ability to control the amygdala. Doing things like reaching out to friends and family for support with stressful events or approaching potentially stressful situations as if they're exciting can help you manage stress and improve your resilience. Other things that promote resilience include filling your life with positive experiences and emotions. Things like reading, listening to music, spending time with loved ones all create positive emotions that can help you cope better with stress in the long run.

Scientists don't yet know how much resilience can do to change the aging process, but it's clear that stress management isn't just a good idea for your mental health. It's good for your DNA too.

Stress and the biology of depression

As scientists learn more about the biology of depression, ongoing exposure to stress hormones impairs the growth of neurons in the hippocampus. Research even suggests possible links between slow neural activity in the hippocampus and depression. On the other hand, depression medications bring relief by increasing the concentration of neurotransmitters, which in turn promotes neurogenesis in the hippocampus.

Many of the meaningful applications of genomic medicine are in the field of pharmacogenomics; which is the study of the relationship between genetic variation and how our bodies respond to medicine. The insights give us Immense benefits because they show us what works. Now, this is why I think this work is important, and timely.

For my part, I'm going to continue to search for molecular treasures in the human genome in the hope of finding novel ways to treat depression, anxiety and help people feel well faster. And maybe help uncover genetic biomarkers responsible for resilience and neuroplasticity.

A word from citochrome wellness

For many people suffering from depression and anxiety, finding the right treatment can seem like an insurmountable challenge. If medication is part of your treatment plan, the DNA approach may help you feel better faster. citochrome wellness can help.

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Disclaimer

The information in this Report is for informational and educational purposes only. It is not intended for direct diagnostic use or medical decision-making without review by a healthcare provider.

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